2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108229S
    6β-Naltrexol-d3
    6β-Naltrexol-d3 (6β-Hydroxynaltrexone-d3) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit.
    6β-Naltrexol-d<sub>3</sub>
  • HY-W700165
    4,5-Desisopropylidene topiramate
    4,5-Desisopropylidene topiramate is the major metabolite of Topiramate (HY-B0122).
    4,5-Desisopropylidene topiramate
  • HY-66008S2
    N-Acetyl mesalazine-13C6
    N-Acetyl mesalazine-13C6 is a deuterated labeled N-Acetyl mesalazine. N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the metabolite of 5-Aminosalicylic Acid (HY-15027) with endoscopic activity. N-Acetyl mesalazine can be used for the research of ulcerative colitis.
    N-Acetyl mesalazine-<sup>13</sup>C<sub>6</sub>
  • HY-A0115S2
    Ramiprilat-d4 hydrochloride
    Ramiprilat-d4 hydrochloride is deuterated labeled Ramiprilat (HY-A0115). Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a Ki value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research.
    Ramiprilat-d<sub>4</sub> hydrochloride
  • HY-135774R
    6-Hydroxybenzbromarone (Standard)
    1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard) is the analytical standard of 1-(Carboxymethyl)cyclohexanecarboxylic acid. This product is intended for research and analytical applications. 1-(Carboxymethyl)cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E) is a potential impurity in commercial preparations of the antiepileptic agent Gabapentin (HY-A0057). It is also used as a precursor for the synthesis of a serotonin (5-HT) receptor subtype 5-HT2A antagonist.
    6-Hydroxybenzbromarone (Standard)
  • HY-W703398
    Monopropyl phthalate
    Monopropyl phthalate is a compound derived from the hydrolysis of Dipropyl phthalate (DPrP). Monopropyl phthalate is hydrolyzed to PA. DPrP shows significant dose-dependent toxic effects on K. brevis.
    Monopropyl phthalate
  • HY-137306
    Pergolide sulfone
    Pergolide sulfone is a Pergolide metabolite.
    Pergolide sulfone
  • HY-W725632
    7-Hydroxy etodolac
    7-hydroxy Etodolac is a metabolite of Etodolac (HY-76251). Etodolac is a non-steroidal anti-inflammatory compound and a cyclooxygenase (COX) inhibitor .
    7-Hydroxy etodolac
  • HY-W743525
    (±)-p-Fluoro pseudoephedrine hydrochloride
    		Control
    (±)-p-Fluoro pseudoephedrine hydrochloride is a metabolite of 4-Fluoromethcathinone. 4-Fluoromethcathinone is a cathinone.
    (±)-p-Fluoro pseudoephedrine hydrochloride
  • HY-164998
    15-Hydroxy Lubiprostone
    15-Hydroxy Lubiprostone is an active metabolite of Lubiprostone (HY-B0679).
    15-Hydroxy Lubiprostone
  • HY-W712534
    N-Acetyl lenalidomide
    N-Acetyl lenalidomide is a metabolite of Lenalidomide (HY-A0003), which is formed by hydrolysis of Lenalidomide in plasma and urine.
    N-Acetyl lenalidomide
  • HY-13256R
    Desmethyl Erlotinib (hydrochloride) (Standard)
    Metoclopramide (hydrochloride hydrate) (Standard) is the analytical standard of Metoclopramide (hydrochloride hydrate). This product is intended for research and analytical applications. Metoclopramide hydrochloride hydrate is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC50s of 308 nM and 483 nM, respectively. Metoclopramide hydrochloride hydrate can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis.
    Desmethyl Erlotinib (hydrochloride) (Standard)
  • HY-170697
    4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-Hydroxyethyl)-docosapentaenamide
    4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-hydroxyethyl)-Docosapentaenamide is a long-chain ω-6 fatty acid with a hydroxyethylamide group attached at the alpha chain.
    4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-Hydroxyethyl)-docosapentaenamide
  • HY-W705371
    α-Hydroxy etizolam
    α-Hydroxy etizolam is the primary metabolite of Etizolam, possessing nearly identical pharmacological potency and high affinity for benzodiazepine receptors as Etizolam.
    α-Hydroxy etizolam
  • HY-10873S1
    N-Desethyl Sunitinib-d4 TFA
    N-Desethyl Sunitinib-d4 (SU-12662-d4) TFA is deuterium-labeled N-Desethyl Sunitinib (HY-10873).
    N-Desethyl Sunitinib-d<sub>4</sub> TFA
  • HY-Z7659
    Lansoprazole sulfone N-Oxide
    Lansoprazole sulfone N-Oxide (Comound 3) is the overoxidized by-product found in the synthesis of the proton pump inhibitor Lansoprazole (HY-13662). Lansoprazole sulfone N-Oxide is promising for research of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome.
    Lansoprazole sulfone N-Oxide
  • HY-108226
    Regorafenib N-oxide and N-desmethyl (M5)
    Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4.
    Regorafenib N-oxide and N-desmethyl (M5)
  • HY-B0300R
    Penicillamine (Standard)
    Penicillamine (Standard) is the analytical standard of Penicillamine. This product is intended for research and analytical applications. Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria.
    Penicillamine (Standard)
  • HY-136456R
    2-NP-AMOZ (Standard)
    2-NP-AMOZ (Standard) is the analytical standard of 2-NP-AMOZ. This product is intended for research and analytical applications. 2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ.
    2-NP-AMOZ (Standard)
  • HY-W615141
    Desmethyltrimipramine
    Desmethyltrimipramine (DTRI) is a metabolite of Trimipramine (HY-B1213A) (a 5-HT receptor antagonist and antidepressant).
    Desmethyltrimipramine
Cat. No. Product Name / Synonyms Application Reactivity